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Troponin bound to heparin results in lessen measured troponin plasma concentration when compared to serum.[76] Other sources of interference which could have an impact on the assay detection method and result in Fake-unfavorable troponin values contain ascorbic acid in immunoenzymometric assays making use of alkaline phosphatase, biotin in assays utilizing a biotinylated antibody, streptokinase from the presence of streptavidin, and high titers of antibodies to ruthenium or streptavidin in cTnT assays.
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Human anti-animal antibodies (HAAA) are large-affinity, precise, polyclonal antibodies created against a particular animal immunogen complete immunoglobulin of IgG or IgM course.[84] They display strong binding with antigens of a single chemical composition. They are developed inside of a substantial titer such that they compete Along with the take a look at antigen by cross-reacting with reagent antibodies of the identical species to produce a Wrong signal.
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